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KMID : 0384119930130040643
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 4 p.643 ~ p.652
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Pulmonary Tuberculosis Is Not Associated with HLA-DR Phenotypes in the Korean Population
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이경화
정기석/최은실/박찬정/조현찬/이규만/김호증/이명구/현인규
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Abstract
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HLA-DR molecule is a polymorphic membrane glycoprotein functioning in the induction of an immune response against pathogens. Many studies studies have tried to identify the association between HLA and susceptibility to tuberculosis in various
populations. Although the mortality rate from tuberculosis is high in Koreans. The association of HLA-DR has not been well studied. To identify a possible association of specific HLA-DR in development of sever tuberculosis, patients with far
advanced
(25 cases) or miliary (9 cases) tuberculosis were selected and their HLA-DR types were examined at the DNA level. The HLA-DRB1 genes were amplified by polymerase chain reaction (PCR) using a DRB locus specific primer set. PCR samples were
analyzed
by
dot blot hybridization using chemiluminescent-labeled sequence specific oligonucleotide probes and DR types assigned by comparison of their hybridization patterns to that of standard cells. There was no significant differences in HLA -DR
frequencies
between overall 34 selected patients and 50 normal controls, although HLA-DR14 exhibited increased tendency in miliary tuberculosis compared to far advanced tuber culosis (5/9 vs. 3/25, P<0.05). Though further studies including a large number of
miliary
tuberculosis patients are necessary to clarify its linkage to specific HLA-DR, these data suggest that severe pulmonary tuberculosis is not associated with HLA-DR in the Korean population.
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KEYWORD
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